Armour Penetration Quints vs Attack Damage Quints.
Which is best to run on an AD champ and why?
I've been running Armour Pen Quints with Armour Pen Marks for a base of 25. But everybody I speak to says the 7 attack damage from AD Quints benefits you more than the 10 Armour Pen.
AD runes if you focus on last hitting
ARP runes if you focus on harassing
This guy made an awesome guide on it, check it: http://www.youtube.com/watch?v=QH2-TGUlwu4
Armour pen of course, it will be more useful mid to late game. Pure damage runes are generally only useful early on (where there are less kill opportunities).
I personally use Flat AD on melee Casters like Renekton. You know, people who rely more on the spells rather than the auto attack.
I use Arm pen on people who need to AA as much as they spellcast. Like Trynd or Lee Sin.
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